Advances in Cancer Biomarkers From biochemistry to clinic for a critical revision

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Content:

Part I Generality
1 Cancer Biomarkers: A Status Quo ………………………………………. 3

Roberto Scatena

2 Cancer Biomarkers Discovery and Validation: State of the Art, Problems and Future Perspectives ……………… 9

Alvaro Mordente , Elisabetta Meucci , Giuseppe Ettore Martorana , and Andrea Silvestrini

3 Use of Biomarkers in Screening for Cancer …………………………. 27

Michael J. Duffy

4 The Role of Metabolomics in the Study of Cancer Biomarkers and in the Development of Diagnostic Tools ………. 41

Jean-Pierre Trezzi , Nikos Vlassis , and Karsten Hiller

5 The Role of Epigenomics in the Study of Cancer Biomarkers and in the Development of Diagnostic Tools ………. 59

Mukesh Verma

6 Effi cient, Adaptive Clinical Validation of Predictive Biomarkers in Cancer Therapeutic Development ………………… 81

Robert A. Beckman and Cong Chen
Part II Tumor Markers – A Critical Revision: Enzymes
7 Prostate Specifi c Antigen as a Tumor Marker in Prostate Cancer: Biochemical and Clinical Aspects ………….. 93

J. W. Salman , I. G. Schoots , S. V. Carlsson , G. Jenster , and M. J. Roobol

8 The Actual Role of LDH as Tumor Marker, Biochemical and Clinical Aspects …………………………… 115

Vladimir Jurisic , Sandra Radenkovic , and Gordana Konjevic

9 Neuron-Specifi c Enolase as a Biomarker: Biochemical and Clinical Aspects ………………………………………… 125

Maria Antonietta Isgrò , Patrizia Bottoni , and Roberto Scatena
10 Components of the Plasminogen-Plasmin System as Biologic Markers for Cancer ……………………………….. 145

Brandon J. McMahon and Hau C. Kwaan
Part III Tumor Markers – A Critical Revision: Hormones
11 The Role of Human Chorionic Gonadotropin as Tumor Marker: Biochemical and Clinical Aspects …………… 159

Lorenza Sisinni and Matteo Landriscina
Part IV Tumor Markers – A Critical Revision: Oncofetal Proteins
12 Biomarkers for Hepatocellular Carcinoma (HCC): An Update ……………………………………………. 179

Dave Li and Shinji Satomura
Part V Tumor Markers – A Critical Revision: Cytokeratins
13 Mucins and Cytokeratins as Serum Tumor Markers in Breast Cancer ……………………………………….. 197

Andrea Nicolini , Paola Ferrari , and Giuseppe Rossi
Part VI Tumor Markers – A Critical Revision: Carbohydrate Markers
14 The Role of CA 125 as Tumor Marker: Biochemical and Clinical Aspects ………………………………………… 229 Patrizia Bottoni and Roberto Scatena
Part VII Tumor Markers – A Critical Revision: Blood Group Antigens
15 CA 19-9: Biochemical and Clinical Aspects ………………………….. 247 Salvatore Scarà , Patrizia Bottoni , and Roberto Scatena
Part VIII: Tumor Markers – A Critical Revision: Genetic Markers
16 Non Coding RNA Molecules as Potential Biomarkers in Breast Cancer ………………………………………………. 263

Kim De Leeneer and Kathleen Claes 17 Urinary Prostate Cancer Antigen 3 as a Tumour Marker: Biochemical and Clinical Aspects ………………………….. 277

Marianne Schmid , Jens Hansen , and Felix K. -H. Chun
Part IX Tumor Markers – A Critical Revision: Various Protein Markers
18 Biomarker in Cisplatin-Based Chemotherapy for Urinary Bladder Cancer ………………………………………………… 293 Thorsten H. Ecke 19 A Critical Approach to Clinical Biochemistry of Chromogranin A ……………………………………….. 317 Patrizia Bottoni , Teresa De Michele , and Roberto Scatena
Part X Receptors as Biomarkers
20 The Actual Role of Receptors as Cancer Markers, Biochemical and Clinical Aspects: Receptors in Breast Cancer

Matthew Brennan and Bora Lim
Part XI Perspectives
21 The Role of CTCs as Tumor Biomarkers ……………………………… 341 Evi S. Lianidou , Athina Markou , and Areti Strati

At present there are a growing number of biomolecules under investigation to understand their potential role as cancer biomarker for diagnostic, prognostic and therapeutic purposes.  Intriguingly, the state of art on cancer biomarkers research shows interesting and promising results together to clamorous failures. Also from a clinical point of view, there are contradictory results on routine clinical use of the present cancer biomarkers. Some patients may be simply  monitored in their course by a periodic blood sample, but sometimes this monitoring shows dramatic limits. A lot of patients show serious and extensive relapses without significant change in serum concentrations of biomarkers tested. Often the physician who should utilize these biomarker does not entirely  know their limits and the total potential applications as well and sometimes this knowledge is influenced by economical and marketing strategies. This limited and “polluted” knowledge may have dramatic consequences for patient.  The aim of this book is to diffuse all aspects of cancer biomarkers, from their biochemical peculiarities to all clinical implications by passing through their physiology and pathophysiology.

This critical approach towards old and new cancer biomarkers should foster a deepened and useful understanding of the diagnostic and prognostic index of these fundamental parameters of laboratory medicine and in the same time facilitating the research of new and more sensitive-specific signals of the cancer cell proliferation.

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