Free Chronomics and Continuous Ambulatory Blood Pressure Monitoring PDF Download

Free Chronomics and Continuous Ambulatory Blood Pressure Monitoring PDF Download

By (author): Kuniaki Otsuka, Germaine Cornelissen, Franz Halberg

This fascinating volume applies the concept of chronomics to the medical treatment of hypertension. It starts with the recent updates on chronomics, the analytic techniques, and their application to community-based assessments. The authors advocate the use of 7-day/24-h records of blood pressure, which is effective for finding masked hypertension, masked morning surge, and other rhythm abnormalities. Most organisms, from cyanobacteria to mammals, are known to use the circadian mechanism. However, our body systems also demonstrate circaseptan (roughly weekly), circannual (roughly yearly), and even longer rhythms. Chronomics monitors the physiological data and then analyzes the superimposed rhythms, isolating the cycles mathematically to determine how organisms and their environment interact. It is the study of interactions among time structures (chronomes) in and around us.

Franz Halberg’s passing shy of his 94th
birthday leaves a void that cannot be fi lled.
He will be remembered for founding the
fi elds of chronobiology, chronomics,
chronoastrobiology and chronobioethics. His
accomplishments are summarized in his over
3,600 scientifi c publications, in cooperation
with colleagues from around the world.
He coined the term circadian (about
24-hour), after documenting “free-running”,
as proof of the endogenicity of circadian
rhythms. As evidence for their importance,
Franz showed that biologic rhythms tip the
scale between health and disease and even
between life and death. Many around the
world call him their mentor and turned to
him for advice, from study design and data
analysis to the interpretation of results in the
time dimension.
His work earned him numerous awards.
Apart from holding professorships in
Laboratory Medicine and Pathology,
Physiology, Biology, Bioengineering and
Oral Medicine at the University of
Minnesota, he received honorary doctorates
from the University of Montpellier (France),
Ferrara (Italy), Tyumen (Siberia), Brno
(Czech Republic), L’Aquila (Italy), and
People’s Friendship University of Russia
(Moscow, Russia).
Born on July 5, 1919 in Romania, Franz
Halberg was brought by the US government
from post-war Austria to Harvard Medical
School, where he held a World Health
Organization fellowship. In 1949, he moved
to the University of Minnesota, which saw
his breakthrough experiments that led to the
important discovery of circadian rhythms,
and then built-in cycles with many other

Cycles in biology have been reported by keen observers since antiquity. Aschoff [1]
suggested that the history of rhythm research began in 650 BC, when the Greek poet
Archilochus of Paros wrote “Recognize which rhythms govern man”. As noted by
Halberg et al. [2], a later fragment by Archilochus refers to the solar eclipse of 6
April 647 BC, which authenticates the fragment on rhythm as dating from the seventh century BC, and identifies Archilochus as a lyric link to both the study of
rhythms and to that of the Sun. In Halberg’s view, the different fragments from the
same poet link rhythms, chronobiology more broadly, and the transdisciplinary
mapping of time structures (chronomes) to space physics.
The opening by day and closing by night of the leaves of the tamarind tree was
reportedly [3] described as the “nyktitropic movement” (now called nyctinasty) during the fourth century BC by Androsthenes of Thasos, who in 324 BC commanded
a ship with 30 oars in the campaigns of Alexander the Great, explored Bahrain and
its flora, and the Arabian coast, and circumnavigated India. His book, now apparently lost, was cited by Theophrastus [4]. It first reports on the fact that plants are
capable of movement, a characteristic that had previously been attributed only to the
animal world. Androsthenes believed that the daily changes from light to darkness
rather than changes in environmental temperature were responsible for the leaf
movements [3].

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