Free Systems Biology of Tumor Physiology Rethinking the Past, Defining the Future PDF Download

Free Systems Biology of Tumor Physiology Rethinking the Past, Defining the Future PDF Download

By (author): David H. Nguyen

This exciting SpringerBrief presents evidence for new ideas that will challenge several theories of how cancer biology is understood. Cancer biology has undergone several intellectual revolutions in the past 50 years. A mutation-centric view of cancer has given way to the tumor microenvironment view. Reductionistic studies of one gene at a time have given way to systems biology approaches that analyze the whole genome (omics) at the same time. However, this text combines the complex levels studying cancer at the molecular biology level, endocrinology level, and transcriptomics level. What researchers are  now realizing is that there is a need to combine omics with physiology concepts in order to better understand cancer and this book will give insight to the merging of these two fields in order to define how cancer is studied in the future.?
Systems biology can be defined as the study of how multiple interacting parts of a living
system affect each other. A tumor is a system of cells that is imbedded in a larger system
of organs, otherwise known as the human body. This book attempts three things from
the systems biology perspective. The first chapter lays out testable reasons why estrogens and macrophages may be mechanisms behind why a lifelong exposure to estrogen
increases breast cancer risk. The second chapter clarifies confusion between the cellular
plasticity and cell-of-origin hypothesis in describing how tumors arise and how tumors
sustain themselves. The third chapter describes common misuses of mouse models of
cancer and how a systems biology perspective can extract so much more useful information from mouse models of cancer.
Free Systems Biology of Tumor Physiology Rethinking the Past

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