Free Therapy for Ocular Angiogenesis Principles and Practice PDF Download

Free Therapy for Ocular Angiogenesis Principles and Practice PDF Download

Features: Used Book in Good Condition
By (author): Arup Das MD PhD, Thomas Friberg MS MD

Ocular angiogenesis, or the abnormal growth of blood vessels in the eye, is the cause of major neovascular eye diseases. In addition, retinal and choroidal neovascularization are the major causes of vision loss in this country. With the new era of anti-angiogenic therapies already in practice, ophthalmologists have started treating many ocular diseases including macular degeneration, diabetic retinopathy, and retinal vascular occlusion using anti-angiogenic drugs.

Therapy for Ocular Angiogenesis: Principles and Practice covers the basic pathophysiology of ocular angiogenesis and strategies for inhibition. The authors discuss the “Principles” of anti-angiogenic therapy, pre-clinical studies, future drugs on the horizon, drug delivery, and the “Practice” of the therapy in many ocular diseases. Vision researchers in both academia and industry, as well as clinician scientists, have contributed chapters on different aspects of the angiogenic process, and clinical strategies to fight it. The book also includes chapters that deal with diabetic macular edema, and various therapeutic options for this condition.

A companion website includes the fully searchable text and an image bank.

However, Wang et al.52 have reported that serum IGF-1
levels did not correlate with proliferative diabetic retinopathy either in type 1 or in type 2 diabetics in their large,
population-based series. The elegant work of Lois Smith
and her co-workers strongly suggests that IGF-1 serves
primarily as a “permissive” factor for neovascularization
occurring in the presence of VEGF, rather than as the principal angiogenic factor itself.53
Angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2),
acting through the receptor Tie2, also serve as permissive factors for vascular growth. In a series of transgenic
mice that can express Ang1 or Ang2 and VEGF, stimulated
by different promoters that are engineered to respond to
dosing with the antibiotic doxycycline, Campochiaro and
colleagues54 have been able to show differential regulation
of vascular sprouting from the superfi cial or deep retinal
capillary beds, governed by the expression of Ang1 or
Ang2 at different postnatal times during the development
of the retinal vasculature in these mice. Although a role
for Ang1 or Ang2 in the adult eye, or in pathological processes such as the proliferative retinopathies, has not been
delineated, Campochiaro speculates that increased expression of one of these molecules may be necessary to permit
neovascularization in the retinas of diabetic humans or
experimental animals, in which VEGF has been upregulated but new vessels have not appeared.8,15,54 Additional
evidence for permissive, or accessory, roles for Ang2 and
the Tie2 receptor in retinal neovascularization has been
presented by other authors.

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