Hematologic Abnormalities and Acute Lung Syndromes (Respiratory Medicine) 1st ed. 2017 Edition

Hematologic Abnormalities and Acute Lung Syndromes (Respiratory Medicine) 1st ed. 2017 Edition

This book provides a unique frame work for examining acute lung syndromes that arise from hematologic disorders or is defined by a hematologic abnormality as a key feature.  Acute lung processes arising from hematologic disorders can present as life-threatening conditions, and as such, the pulmonary physician or critical care physician are often directly involved in care or called upon to provide expertise. Chapters are organized into three sections, each with an emphasis on pathogenesis and current understanding of mechanisms. The text begins with the central theme of the lungs as the direct interface between the external environment and blood, description of individual components of the hematopoietic system, their function and relevance to the lungs. The second section outlines both benign and malignant primary hematologic disorders that can lead to acute pulmonary manifestations. The final section focuses on acute lung syndromes stemming from complications of transfusion and treatment. Chapters are presented in an easy-to-access format, providing information on diagnosis, management, and outcomes. This is a valuable resource for pulmonary fellows in training, pulmonologists, critical care physicians, and physicians involved in caring for patients in the ICU.

Standard textbooks in Respiratory Medicine do not typically organize their contentsto specifically address hematologic abnormalities in acute lung syndromes.
However, the main function of the lung is gas exchange at the interface between the xternal environment and blood. Thus, by defiition, blood and its components are an integral part of the lungs and, given the large surface area of the pulmonary vascular beds, the lungs harbor a significant fraction of the circulating blood volume at any one time. While red cells are the vehicles for gas transfer, platelets provide hemostasis, and leukocytes vital for lung homeostasis and immunity, components of the hematopoietic system, can also serve as agents of injury to the lungs in disease states. So, it is not surprising that primary hematologic disorders or disorders secondary to immunopathology can lead to acute lung dysfunction. The purpose of this book is to provide a unique framework for acute lung syndromes that arise from hematologic disorders or is defined by a hematologic abnormality as a key feature.
These acute lung processes can present as life-threatening conditions, and as such, the pulmonary physician or critical care physician is often directly involved in their care or called upon to provide expertise. The book emphasizes the pathogenesis and current understanding of mechanisms and is organized into three parts. It begins with an overview containing the central theme of the lungs as the direct interface between the external environment and blood and a description of individual components of the hematopoietic system, their function, and relevance to the lungs. The overview also discusses the concept of the lungs as an organ site of leukocyte sequestration and a target organ of injury and how cells of hematopoietic origin can serve as agents of injury. The second part of the book focuses upon primary hematologic disorders that can lead to acute pulmonary manifestations. This section is organized by benign and malignant hematologic disorders and the specific clinical entities affecting the lungs associated with these disorders. The third part of the book focuses upon transfusion-related complications occurring in the ICU setting.
These chapters provide a unique framework for discussing unusual clinical entities encountered largely in the acute hospital setting. These acute pulmonary syndromes are typically not organized in such a way for easy reference. However,vi recent advances in medicine have allowed for patients with severe comorbidities
such as sickle cell anemia, hemophilia, hematologic malignancies, or immunopathologies to survive, and thus many of the syndromes discussed have not had full representation in respiratory medicine textbooks historically. Thus, the book encompasses disease entities that specialists will encounter. The book is written in detail, emphasizing primary literature and pathophysiology, and catered to clinicians who take care of these patients  

Part I Overview
1 The Lung–Blood Interface …………………………………………………………… 3
Peng Zhang and Janet S. Lee
2 Leukocyte Kinetics and Migration in the Lungs……………………………. 19
Prithu Sundd and Margaret F. Bennewitz
Part II Acute Pulmonary Manifestations Arising
From Primary Hematologic Disorders
3 Sickle Cell Disease and Acute Chest Syndrome:
Mechanisms and Pathogenenesis………………………………………………….. 49
Olufolake Adetoro Adisa , Amma Owusu-Ansah ,
Afua Darkwah Abrahams , Samit Ghosh ,
and Solomon Fiifi Ofori-Acquah
4 Sickle Cell Disease and Acute Chest Syndrome:
Epidemiology, Diagnosis, Management, Outcomes ……………………….. 67
Justin R. Sysol and Roberto Machado
5 Thrombophilias and Acute Pulmonary
Thromboembolic Disease …………………………………………………………….. 89
Shani Gunning-Carter , Gregory J. Kato , and Belinda Rivera-Lebron
6 Bleeding Disorders: Diagnosis and Treatment of Hemorrhagic
Complications in the Intensive Care Unit……………………………………… 109
Craig D. Seaman and Margaret V. Ragni
7 Acute Pulmonary Manifestations of Hematologic Malignancies…….. 131
Andra Fee-Mulhearn and Patrick Nana-Sinkam
8 Acute Pulmonary Complications of Bone Marrow
and Stem Cell Transplantation …………………………………………………….. 147
Guang-Shing Cheng and David K. Madtesviii
Part III Transfusion-Related Complications
9 Storage Lesion: Evolving Concepts and Controversies………………….. 175
Stefanie Forest , Francesca Rapido , and Eldad A. Hod
10 Transfusion and Acute Respiratory Distress Syndrome:
Pathogenesis and Potential Mechanisms ………………………………………. 193
Nicole P. Juffermans and Alexander P. Vlaar
11 Transfusion and Acute Respiratory Distress Syndrome:
Clinical Epidemiology, Diagnosis, Management, and Outcomes ……. 213
Hannah C. Mannem and Michael P. Donahoe
12 Transfusion Associated Circulatory Overload ………………………………. 229
Mario V. Fusaro and Giora Netzer
13 Transfusion-Related Immunomodulation (TRIM):
From Renal Allograft Survival to Postoperative Mortality
in Cardiac Surgery………………………………………………………………………. 241
Eleftherios C. Vamvakas
Index………………………………………………………………………………………………….. 261

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