Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart

Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart

This book is an authoritative, concise reference on the histological and genetic typing of tumors of the lung, pleura, thymus and heart. Prepared by 200 authors from 25 countries, it contains more than 670 color photographs, numerous MRIs, ultrasound images, CT scans, charts and approximately 2200 references. Diagnostic criteria, pathological features and associated genetic alterations are described in a strictly disease-oriented manner. Sections on all recognized neoplasms and their variants include new ICD-O codes, incidence, age and sex distribution, location, clinical signs and symptoms, pathology, genetics and predictive factors.

This book is in the series commonly referred to as the "Blue Book" series. Pathology and Genetics of Tumors of the Lung, Pleura, Thymus and Heart

Lung cancer is the most common cancer in the world today (12.6% of all new cancers, 17.8% of cancer deaths). There were an estimated 1.2 million new cases and 1.1 million deaths in 2000; the sex ratio (M:F) is 2.7. Lung cancer is relatively more important in the developed than developing countries as it accounts for 22% versus 14.6% of cancer deaths, respectively. In developed countries, geographic patterns are very much a reflection of past exposure to tobacco smoking {505}. In men, the areas with the highest incidence and mortality are Europe (especially Eastern Europe), North America, Australia/New Zealand, and South America. The rates in China, Japan and South East Asia are moderately high, while the lowest rates are found in southern Asia (India, Pakistan), and subSaharan Africa. In certain population subgroups (e.g. US blacks, New Zealand
Maoris), incidence is even higher, and with current incidence rates, men in these two groups have about a 13% chance of developing a lung cancer before the age of 75.
In women, the geographic pattern is somewhat different, chiefly reflecting different historical patterns of tobacco smoking. Thus, the highest incidence rates are observed in North America and North West Europe (U.K., Iceland, Denmark) with moderate incidence rates in Australia, New Zealand and China

Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart

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